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Key Takeaways
- Fifth Third is acquiring Comerica, and the combined company, if approved, would be one of the 10 largest banks in the U.S.
- Though this year has seen its share of mergers and acquisitions in the financial sector, the deal between Fifth Third and Comerica represents the biggest bank deal in the country thus far in 2025.
Fifth Third and Comerica have entered into a merger agreement that will see Fifth Third acquire Comerica in a stock purchase with a value of nearly $11 billion.
If approved, Fifth Third will have a presence across the country, including in California and Texas. Credit card issuers may face a more formidable foe in Fifth Third, which plans to have additional influence in the credit card arena following the merger.
Fifth Third and Comerica both rank among the largest 35 banks in the country in terms of consolidated assets, according to Federal Reserve data.
Together, the companies would form the ninth-largest bank in the U.S., according to the press release on the merger.
The acquisition will allow Fifth Third to increase the speed of its strategy to build density in markets it considers to be high-growth, said Tim Spence, Chairman, CEO, and President of Fifth Third, in the release.
“Comerica’s strong middle market franchise and complementary footprint make this a natural fit,” Spence said. “Together, we are creating a stronger, more diversified bank that is well-positioned to deliver value for our shareholders, customers, and communities — starting today, and over the long-term.”
Credit card issuers that would compete with Fifth Third after the merger should consider what exactly a stronger version of the bank will bring to the card space. Many of those issuers may be competing with Fifth Third for cardholder business for the first time following the company’s acquisition of Comerica.

The combined financial institution would have a presence in 17 of the top 20 markets in the U.S., in terms of growth rate, according to the press release.
And a TD Cowen analyst said that Fifth Third, after its acquisition of Comerica, will be among the top five banks in major Midwest metropolitan statistical areas, according to a Reuters report.
Fifth Third’s plans to win more customers in the regions where it would operate following merger approval are still unclear, but the bank may roll out special offers to catch the eyes of prospects.
For instance, the company may introduce promotions in territories it’s expanding into that offer cardholders favorable terms on balance transfers for a limited time.
“This merger presents an exciting opportunity to bring the best of Fifth Third’s digital banking experience and consumer product innovation to more people,” Ben Mendelsohn, Fifth Third’s Director of Product Management, told us when reached for comment.
“We look forward to expanding access to the tools and capabilities that have earned us recognition for customer satisfaction and digital excellence,” Mendelsohn continued.
The Time is Right for Mergers
This year has seen some high-profile deal announcements take place in the banking sector, including PNC’s recent notice that it’s acquiring First Bank and the news from Pinnacle Bank and Synovus that the two institutions are merging.
But Fifth Third’s acquisition of Comerica is the largest bank deal in the U.S. thus far this year. And it’s only October, leaving plenty of time for another merger to come along this year that‘s even bigger than that between Fifth Third and Comerica.
Regional banks in the U.S. are choosing to grow via mergers more often these days, in part because they expect a lighter regulatory approach under President Donald Trump’s administration, according to a new Reuters report.
The merger between Fifth Third and Comerica comes on the heels of the news of PNC’s acquisition of First Bank.
The Trump administration’s favorable position on business played a role in the timing of the deal with Fifth Third, Curtis Farmer, Comerica’s Chairman, President, and CEO told Reuters.
“The shifting regulatory environment has gotten more conducive to M&A, and we saw windows starting to open where there might be a chance for us to consider partnering with another institution,” Farmer explained, adding that the parties in the deal would not be moving ahead at this time if they didn’t feel they had support from regulators as well.
Fifth Third’s Board of Directors will welcome three members of Comerica’s board to allow for business continuity following the merger, and Farmer will take on the role of Vice Chair.
The companies expect the transaction, which is subject to approvals from shareholders, to close at the end of Q2 2026.
